Lysophosphatidylserine receptor GPR34-Gi complex
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8iz4
Q-score: 0.52
Gong W, Liu G, Li X, Wang Y, Zhang X
To Be Published
- Cholesterol (386 Da, Ligand)
- [(2~{r})-2-oxidanyl-3-phosphonooxy-propyl] octadecanoate (438 Da, Ligand)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Serine (105 Da, Ligand)
- Lysops-gpr34-gi-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 34 (64 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of Lys05 bound GPR30-Gq complex structure
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xof
Q-score: 0.551
To Be Published
- Nanobody35 (Complex from Lama glama)
- Gpr30-gq (Complex from Homo sapiens)
- G-protein coupled estrogen receptor 1 (42 kDa, Protein from Homo sapiens)
- Lys01 (440 Da, Ligand)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Gpr30-gq complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G protein subunit q (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of apo-GPR30-Gq complex structure
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8xog
Q-score: 0.462
To Be Published
- Gpr30-gq (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha-q (41 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from synthetic construct)
- G-protein coupled estrogen receptor 1 (42 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Water (18 Da, Ligand)
- Gpr30-gq complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8j6i
Q-score: 0.443
Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J
Cell Rep (2023) 42 pp. 113406-113406 [ Pubmed: 37952153 DOI: doi:10.1016/j.celrep.2023.113406 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Complex of hydroxycarboxylic acid receptor 2 with mk-6892 (Complex from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Hydroxycarboxylic acid receptor 2 (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
PhK holoenzyme in inactive state, muscle isoform
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jfk
Q-score: 0.265
Yang X, Zhu M, Lu X, Wang Y, Xiao J
Nat Commun (2024) 15 pp. 2719-2719 [ DOI: doi:10.1038/s41467-024-47049-2 Pubmed: 38548794 ]
- Farnesyl (206 Da, Ligand)
- Phosphorylase b kinase, muscle isoform (Complex from Homo sapiens)
- Phosphorylase b kinase regulatory subunit beta (125 kDa, Protein from Homo sapiens)
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (45 kDa, Protein from Homo sapiens)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (137 kDa, Protein from Homo sapiens)
CryoEM structure of Gi-coupled TAS2R14 with cholesterol and an intracellular tastant
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8vy7
Q-score: 0.52
Kim Y, Gumpper RH, Liu Y, Kocak DD, Xiong Y, Cao C, Deng Z, Krumm BE, Jain MK, Zhang S, Jin J, Roth BL
Nature (2024) 628 pp. 664-671 [ Pubmed: 38600377 DOI: doi:10.1038/s41586-024-07253-y ]
- Cholesterol (386 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
- 4-methyl-n-[(2m)-2-(1h-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine (321 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Ternary complex of tas2r14 with gi heterotrimer (Complex from Homo sapiens)
- Taste receptor type 2 member 14 (70 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
CryoEM structure of Ggust-coupled TAS2R14 with cholesterol and an intracellular tastant
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8vy9
Q-score: 0.479
Kim Y, Gumpper RH, Liu Y, Kocak DD, Xiong Y, Cao C, Deng Z, Krumm BE, Jain MK, Zhang S, Jin J, Roth BL
Nature (2024) 628 pp. 664-671 [ Pubmed: 38600377 DOI: doi:10.1038/s41586-024-07253-y ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(t) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- 4-methyl-n-[(2m)-2-(1h-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine (321 Da, Ligand)
- Ternary complex of tas2r14 with ggust heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Taste receptor type 2 member 14,gpcr,taste receptor type 2 member 14 (72 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of the MM07-bound human APLNR-Gi complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xzh
Q-score: 0.649
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Mm07 (1 kDa, Protein from synthetic construct)
- Cryo-em structure of the mm07-bound human aplnr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the CMF-019-bound human APLNR-Gi complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8xzi
Q-score: 0.588
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Scfv16 (26 kDa, Protein from synthetic construct)
- (3~{s})-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazol-5-yl]carbonylamino]hexanoic acid (455 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the cmf-019-bound human aplnr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Structure of Apo CXCR4/Gi complex
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8u4n
Q-score: 0.56
Saotome K, McGoldrick LL, Ho J, Ramlall T, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC
bioRxiv (2024) [ DOI: doi:10.1101/2024.02.09.579708 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- C-x-c chemokine receptor type 4 (71 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Apo cxcr4/gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)